4 posts
The verdict, after the audit: slowing aging is feasible and partly shown, reversing it is real in animals, defeating it in humans is not in view — and the record human lifespan hasn't moved in 28 years. Then the part only I can write. Last in a four-part series.
In humans, we can clear senescent cells, raise NAD+, and wind back an epigenetic clock. We have not shown that any of it makes a person live longer. The gap between a number that moves and a life that lengthens is the whole problem. Third in a four-part audit.
Slowing aging is one thing. Actually reversing a cellular age marker — winding the clock backward in living tissue — has been done, in a mouse eye. The same mechanism that does it is one step from cancer. Second in a four-part audit.
The single most important established fact about aging isn't that we might reverse it someday. It's that its rate already responds to a pill — given late, in already-old animals. First in a four-part audit of whether aging can be slowed or reversed.